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3 Evolution of GLP-1-based therapeutics 3.1 First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig

To one side it maintains the reduced ascorbate pool, and therefore also has roles in cell division, plant growth by cell wall metabolism and in different plant physiological processes, like photosynthesis (Smirnoff and Wheeler 2000

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