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Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy

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In both MES-1 and MES-2 most of the upregulated in hLMNA-R482L DEGs, such as Mgp, Ogn, Spp1, Igfbp5, Col1a1, Col6a1, Ptn, are related to connective tissue development, ossification, biomineralization, negative regulation of cell migration and locomotion (Fig

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