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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

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Thus, it is reasonable to speculate that better neuronal function following CAR treatment may be associated with BBB protection and suppression of the ROS/NF-B/MMP-9 pathway