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doi: 10.1530/EJE-16-0616 266 CaiYYangFHuangX
More serious but uncommon side effects are typically linked to high or frequent dosing
No treatment produces overnight transformation
In malignancy, this constitutes a constitutive, irreversible metabolic adaptation driven by oncogenic signaling (e.g., HIF-1 stabilization, c-Myc amplification) that supports uncontrolled proliferation independent of oxygen availability
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