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The fact that the lean body mass decreased from four to eight weeks in the Setria and placebo groups suggests bad experimental design (the researchers hypothesized "eating less" and "over-reaching") -- these variables should be better accounted for in a proper study

Mol Neurobiol 55(8):69846999

Importantly, REDEFINE 1 also showed that a significant proportion of participants achieved 25% body weight reduction a threshold that, in clinical terms, represents the kind of weight loss previously achievable only through bariatric surgery

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