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Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety
One potential factor is rapid weight loss
Cardiovascular Impact: Smoking cannabis can temporarily raise heart rate and blood pressure, which may be relevant for those with existing cardiovascular risk factors
Interestingly, Ipamorelin helped to increase body fat in GH-deficient mice by 15% within two weeks [8]
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