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however, it results in increased levels of hydrogen peroxide and defects in certain cellular pathways
The rise in plasma GLP-1 is clearly meal related with fasting levels of about 5-15 pM and stimulated levels of 40-80 pM in normal men (59, 90)
This is the same principle behind why recombinant protein biologics (monoclonal antibodies, insulin analogues) are never shaken: air-water interfacial agitation unfolds polypeptide chains that then reassemble into non-native oligomers or fibrils
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