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Challenges and Future Directions: A Rheumatologist Perspective These multiple effects make GLP-1 drugs an exciting prospect in autoimmune disease treatment

Nephrotic syndrome Clinical and experimental data have demonstrated profound disturbances of IGF-1/-2 and its binding proteins in the circulation and urine, which were originally thought to be due to increased glomerular permeability and urinary losses of these proteins [215, 216]

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