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Related impurities in peptide medicines
In the dose-finding phase 2 trial, the hemoglobin A1c (HbA1c) reduction from baseline to 26 weeks was 0.7% to 1.9% with varying doses of oral semaglutide (2.5 to 40 mg once-daily), 0.3% with placebo, and 1.9% with 1 mg of once-weekly subcutaneous semaglutide [20]
Specifically, Col I, Col III and TGF-1 expression levels were examined using western blotting and the CVF was assessed by Masson's trichrome staining
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