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While GLP-1 and GIP primarily regulate insulin secretion and appetite pathways, the addition of glucagon receptor signaling actively allows researchers to study direct increases in cellular energy expenditure, enhanced lipolysis, and accelerated hepatic lipid metabolism
This includes limiting alcohol consumption, managing stress, and getting adequate sleep
Furthermore, by addressing metabolic dysfunction in obese patients, whose prevalence is increasing in the IBD population (13), GLP-1 RAs could indirectly mitigate inflammation by decreasing the pro-inflammatory activity of adipose tissue, particularly visceral adipose one
This trend raises the question of why people are living longer and what is responsible
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