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GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]

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The significant decrease in the infarct area, brain lesion, and apoptotic cells but the increase in neurogenesis positive cells number and trophic factors appeared in the stroke serum pretreated MSCs compared to the normal serum pretreated [146]

Clinical studies show dietary supplementation with acetyl-L-carnitine may promote neuronal effects such as promoting healthy cell proliferation