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A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity

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They further developed a diagnostic model, OAMGS, based on four marker genes (VEGFA, CDKN1A, PIM3, MAFF) using machine learning, validated in both human and rat models (Lin et al., 2025)