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Potential risks include unpredictable pharmacokinetic interactions, immunogenicity, injection site reactions, gastrointestinal adverse effects, and disruption of copper homeostasis
Certain bacterial species and their metabolic products, particularly short-chain fatty acids like butyrate and propionate, may stimulate L-cell secretion
Pfizer/Metsera is testing MET-097i at both once-weekly and one-monthly regimens in phase 2 trials
This results in higher levels of intracellular glutathione
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