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If you have been on an adequate dose for 8-12 weeks with confirmed proper technique, storage, and supportive lifestyle factors, and you are still seeing no response whatsoever, you may be a non-responder to this particular medication

Virtually no drug trials published to date have used any validated dietary questionnaires, food recalls, etc so this side of the equation remains a "black box"

When food sits longer, theres a higher chance of it refluxing back into the esophagus, which can cause heartburn, bloating, or a sour taste

doi: 10.1177/2040622315620180 35 CuomoA.BolognesiS.GoracciA.CiuoliC.Beccarini CrescenziB.MainaG.et al