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While targeting extracellular collagen processing through LOX/LOXL inhibition has the potential to attenuate postischemic fibrosis, 232 clinical trials of LOXL2-blocking simtuzumab have proven ineffective due to enzymatic redundancy

2 Methods 2.1 Search strategy To identify published studies, we conducted a comprehensive search of PubMed and Embase databases, covering records up to January 2025

The slow protein reduction was analyzed at a single substrate concentration in the presence of 0.1 M glutaredoxin and 0.8 mM GSH

therefore, systemic corticosteroids are not recommended in the updated UK guidelines for the management of SJS/TEN [12]