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Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables

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A recent study further identified that diabetic rats treated with PLP experienced a reduction in problems associated with diabetes, including a decline in oxidative stress parameters, reductions in blood glucose levels, and damage recovery in the liver and kidneys (Abdullah 2019)

In the context of impaired glutathione metabolism, two converging factors promote PGA accumulation