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patients should be monitored for thyroid symptoms as per SmPC guidance Diabetic retinopathy complications : potential worsening in patients with pre-existing retinopathy, particularly with rapid HbA1c reductions (observed with semaglutide) The safety profile of microdosing specifically has not been established through clinical trials

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For instance, the SELECT trial reported a 20% reduction in major adverse cardiovascular events among participants using Semaglutide compared to a placebo