Expect somewhere between 0.5kg and 2kg in week one depending on your starting weight, how much your appetite drops, and your hydration levels
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The Cleveland Clinic also calls berberine a "promising supplement" for weight loss
Human relevance would require sufficient published, peer-reviewed controlled human studies, safety evaluation, pharmacokinetic understanding, toxicology data, and regulatory reviewevidence that has not yet been established at the level required for clinical or consumer-use conclusions