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As expected in Figure S20, our results showed a modest induction of cell death in normal cells, indicating a favorable safety profile for the targeting drug with minimal impact on healthy cells
This increase is driven by the sequential actions of two enzymes: CD39, which converts ATP to AMP, and CD73, which converts AMP into adenosine
In rats, the drugs, known as glucagon-like-peptide-1 (GLP-1) receptor agonists, have been shown to cause thyroid C-cell tumors
While limited, the available clinical data collectively indicate that failure to regulate DNL is a central feature of liver lipid accumulation in NAFLD patients
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