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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia
Moreover, it is prohibited for pregnant women, those in the lactation period, and patients with severe chronic diseases
The data is sobering for both medications
Systemic side effects are rare but can include mild diarrhea, anxiety, or heart palpitations
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