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Importantly, loss of GSTP1 expression in the cisplatin-resistant A2780 subline A2780DPP was toxic to the cells in the presence of cisplatin, consistent with an important catalytic role for GSTP1 in glutathione conjugation in the detoxification pathway of platinum drugs
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in crohns disease
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