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extensive post-market safety data Advantage : Tirzepatide Liver Fat Reduction# Retatrutide : Significant hepatic fat reduction via glucagon receptor activation (up to 82% reduction) Tirzepatide : Moderate hepatic fat reduction observed in trials Advantage : Retatrutide Dosing Convenience# Retatrutide : Once-weekly subcutaneous injection Tirzepatide : Once-weekly subcutaneous injection with established titration schedule Advantage : Neither (tie) Summary and Verdict# Tirzepatide is the proven choice with FDA approval and extensive clinical data