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Glutathione is a substance that the body can make itself from the amino acids cysteine, glycine and glutamic acid
They mimic the action of naturally occurring GLP-1, a hormone released by the intestine in response to food intake
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However, in contrast to anti-hyperlycemic agents such as metformin, pioglitazone and peroxisome proliferator-activated receptor gamma (PPAR) agonists, which were particularly well studied in this matter, very few clinical studies concerning the effects of GLP-1R targeting therapeutics on alleviation of depressive symptoms in humans have been carried out so far [118, 119]
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