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Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma
Gamma-H2AX, generated from the rapid phosphorylation of H2AX histone protein at the serine-139 position in early response to a broad range of DNA lesions, is a highly effective biomarker for DNA strand breaks and DNA oxidation and plays a central role in sensing and repairing DNA damage [52,53,54]
Therapeutic strategies and biomarkers to modulate PARP activity for targeted cancer therapy
Peptide bonds are cleaved by proteolytic enzymes in the GI tract within minutes of ingestion
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