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Severity of fatigue and its relationship with tsh before and after levothyroxine replacement therapy in patients with primary hypothyroidism

Diabetes Obes Metab 24(2):239246

If any apply, the medication should not be prescribed: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known serious hypersensitivity to the active medication or to a related incretin-receptor agonist Clinical precautions that prompt careful screening These are not absolute contraindications on the FDA label, but they meaningfully change the risk-benefit conversation

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