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Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials 3,10,11 , which together with their complementary action on glucose and lipid metabolism spurred the development of PPAR/ dual agonists (Glitazars) for the treatment of type 2 diabetes (T2D) and dyslipidaemia 1
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Roughly half of people included in the study discontinued them during the study period
results showed HbA1c reductions up to 2.02 percentage points with 12 mg [3], modestly exceeding the semaglutide result, though again the trials are not directly comparable
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