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In spite of growing interest in the use of NAD + precursors as a strategy for healthy aging, the in vivo pharmacokinetics remain poorly understood
Certain natural compounds may support GLP-1 production, but they do not replicate the effects of prescription GLP-1 receptor agonists
However, this effect was abolished by a GLP-1 antagonist, subdiaphragmatic vagotomy, or M3 muscarinic receptor blockade, via a mechanism similar to GLP-1R signaling, manifested by alteration in phosphorylation of AKT and STAT3
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