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Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease
When HbA 1c was measured in %, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 0.38% [95% CI 0.75% to 0.01%]), 1.0 mg (MD = 0.45% [95% CI 0.60% to 0.31%]) and 0.5 mg (MD = 0.51% [95% CI 0.68% to 0.33%]), respectively (ESM Table 7)
For example, the pituitary models described by Micic et al
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