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Endometrial cancer risk is cumulative and dose dependent, reinforcing the need for periodic evaluation of abnormal uterine bleeding irrespective of progestogen co-therapy

It should be avoided in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

Its most common side effects are gastrointestinal issues like nausea and diarrhea (sometimes severe enough that patients report not making it to the bathroom in time)

Surgical options: Uterine fibroid embolization is an advanced technique where small pellets are inserted inside the uterus and block the fibroids blood supply