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Crit Care Med
Standard oral supplements often suffer from poor bioavailability, which can lead to digestive side effects
Adipose tissue-derived free fatty acids (FFAs) impair renal urate excretion via URAT1 upregulation, while hyperuricemia reciprocally induces insulin resistance and endothelial dysfunction through AMPK inhibition and oxidative stress (Xu et al., 2015)
The usual dose is 1000 mcg
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