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Cigarette smoke contains a variety of toxic substances, including free radicals and heavy metals, that generate ROS both directly in the male reproductive tract and indirectly through systemic oxidative stress
Therefore, examining mTOR pathway suppression by targeting GPX4 can provide further mechanistic insight into mTOR pathway signaling as a potential therapeutic target for advanced thyroid cancers
5.3 Therapeutic strategies to enhance antioxidant defense Given the limitations of sperms natural antioxidant defenses, therapeutic strategies aimed at enhancing antioxidant capacity are essential for protecting sperm from oxidative stress and improving male fertility (103)
Agents 32 , 405410 (2008)
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