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The 5-on/2-off idea borrows from GH-therapy practice, where periodic breaks are used with the aim of limiting receptor down-regulation

Liver-specific PKC knockout mice fed a high-fat diet exhibited approximately 67% reduction in IR, whereas cellular studies confirmed that PKC activation is associated with impaired insulin signaling in skeletal muscle [34, 35]

The body compensates by increasing glucose oxidation and, more problematically, by increasing amino acid catabolism, which means breaking down muscle protein for energy

These issues are further exacerbated by the current lack of comprehensive production quality management standards (cGMP) specifically tailored for nanomedicines