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Although this variability may have introduced an unquantifiable risk of bias, we conducted multiple secondary analysesmost of them prespecifiedwith the aim of mitigating this heterogeneity and improving the clinical applicability of our findings

[1] They are also not recommended during pregnancy or for women planning pregnancy without appropriate consultation with healthcare providers

Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor Tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study

Yield: 941 mg, 91%