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Overall, the proteomic data indicated that semaglutide effectively mitigated hepatic lipid deposition and key pathways related to fatty acid/lipid protein signalling and fibroblast proliferation ( Figure S11 ), further supporting our histological and single-cell RNA sequencing findings

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals