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Some promoters, like those of GSTU11 and GSTF7 , contained an outstandingly large number of W-boxes (8 and 7 copies, respectively) (Figure 3), which was already reported in the case of GSTF7 (Li et al., 2004)

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HPLC and mass spec purity verification: A credible COA reports purity by high-performance liquid chromatography, typically 98% or higher, alongside mass spectrometry data confirming the peptide's molecular identity and sequence

Consequently, when Nrf2 signaling is blocked, these indirect bone-protective effects of metformin may be diminished or inconsistent, contributing to the observed variability in trabecular bone outcomes in Nrf2 KO mice