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They can lead to weight loss by: Suppressing your appetite : GLP-1s communicate with your stomach and brain to regulate your appetite

GLP-1 receptor activation: appetite suppression, delayed gastric emptying and improved glucose homeostasis

COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)

Zepbound injection pens cost $1,060/month without insurance or discounts, but patients with a prescription can get single-dose vials at either a 2.5- or 5-milligram dosage for $399 and $549 per month, respectively