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Contact your GP for B12 testing if you have: Symptoms suggesting deficiency (persistent fatigue, pins and needles, memory problems, glossitis) Risk factors for deficiency (vegan diet, gastric surgery, long-term metformin or proton pump inhibitor use) [1] [4] Concerns about whether your current supplementation dose is appropriate Underlying conditions affecting B12 metabolism (kidney disease, liver disease) Unexplained high B12 levels on a blood test when not taking supplements Routine monitoring is essential for patients receiving therapeutic B12 injections

Development was limited by gastrointestinal tolerability and later discontinued after safety concerns in clinical development, illustrating the challenge of balancing oral incretin efficacy, tolerability, and safety

Aleem E, Nehrbass D, Klimek F, et al

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