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Rats with DPP-4 deficiency display enhanced adiponectin levels along with attenuated adipose tissue inflammation and insulin resistance [86]
A valid stability-indicating method must: Resolve the main peptide from all degradation products Detect impurities at low regulatory thresholds Accurately quantify impurities even in stressed samples Forced degradation samples are therefore essential during method development and validation for GLP-1 peptide drugs
Kothare PA, Linnebjerg H, Skrivanek Z, Reddy S, Mace K, Pena A, et al
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