what to expect after first injection of semaglutide Injection: Timeline & Happens First Week on Ozempic: What

The risk exists with both medications

Generally, except for semaglutide at a 2.4 mg dose, weight loss with anti-obesity medications is typically between 37% over 612 months, with only a limited number of patients experiencing weight loss above 10%, and even fewer surpassing 15%, compared to those taking a placebo

The numbers come from the STEP 1 trial of semaglutide 2.4 mg, which is the most rigorous long-term data available, with real-world variation noted where it matters

Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog Mix 70/30