Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly
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Discussion GLP-1/exendin-4 Suppresses GABA Currents of Rat GCs by Activating GLP-1R Although GLP-1 and GLP-1R agonists have been reported to regulate AMPA receptors and GABA A receptors in central neurons [14, 57,58,59,60], no data concerning the regulation of ligand-gated channels of retinal neurons by GLP-1/GLP-1R agonists were available
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