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Clearance The clearance rate of semaglutide is 0.039 L/h according to one clinical study

UCK2 (which converts uridine to UMP) in particular requires ATP as a substrate 63 and has been linked with mitochondrial function 64 and mTOR signalling 65

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For other autoimmune conditions, no specific contraindications have been identified beyond the general GLP-1 precautions, but individual risk-benefit assessment with a healthcare provider is essential