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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

Studies have revealed that IF increases microbial diversity, particularly enriching beneficial taxa such as Bifidobacteria and Akkermansia muciniphila , which are crucial for maintaining gut barrier integrity, reducing intestinal permeability, and supporting systemic metabolic health [80]

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If you want direct benefits for skin, immune balance, or rapid antioxidant defense , glutathione may be the more effective choice