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Specifically, cryostress increases plasma membrane permeability, which in turn promotes excessive generation of reactive oxygen species (ROS) and exacerbates lipid peroxidation (LPO)
It is necessary for cell growth, cell replication, blood flow and synthesis of nucleoproteins and myelins, largely due to its effects of methionine metabolism, folic acid and malonic acid
Consequently, IL-6/STAT3 signaling is correlated with tumor progression, invasion, and immune evasion [174]
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