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Introduction Like that in mammals, the complement system also plays crucial roles in the innate immune defense of teleost fish ( Danio rerio ) has eight C3 ( Cyprinus carpio ) has five C3 ( In vertebrates, phagocytosis of leukocytes plays important roles in the immune defense of pathogens, as well as in the initiation of adaptive immunity ( + T cell activation ( Oncorhynchus mykiss ) IgM + and IgT + B cells ( + B cells, including IL-10 ( The C3aR is a seven-transmembrane G protein-coupled receptor which has been widely characterized in mammals ( + B cells and, to a lesser extent, all granulocytes ( Oncorhynchus mykiss ) head kidney leukocytes (HKLs) ( Ctenopharyngodon idella ) C3.1 (the most abundant C3 molecule in grass carp), synthesized the C-terminal peptide of C3a.1 (C3a.1-CP), and found that GST-C3a.1 and C3a.1-CP both could significantly enhance the phagocytic activity of IgM + B cells
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