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Metabolic control of CD8 + T cell fate decisions and antitumor immunity
For example, lymphoid-specific helicase (LSH), a DNA methylation modifier, can activate lipid metabolism-associated genes to inhibit ferroptosis by interacting with WDR76 (Jiang et al., 2017), and together with another W40 protein DCAF8, they function as a crucial nexus in epigenetic regulation of ferroptosis, controlling LSH degradation by adapted oxidative damage sensing through DNA hydroxymethylation (Huang et al., 2020)
Supplements may only be of assistance if dietary intake is inadequate
The safety and effectiveness in children younger than six have not been established
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