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Structured lifestyle interventionsincluding supervised nutrition coaching, behavioral therapy, and exercise programsproduce weight loss of 5-10% over 6-12 months for many people

It did find that the percentage of weight lost from muscle mass was similar between the groups, while the semaglutide group lost more mass overall

Stephen Appezzato Key Takeaways Federal exclusion of weight-loss drugs forces Medicare GLP-1 utilization into other FDA-approved indications, even as 2024 Part D gross GLP-1 spending reached $27.5 billion across 21.8 million claims

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