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We dissect how these rationally engineered platforms overcome the unique physical and cellular barriers of the osteosarcoma TME, with a critical emphasis on the severe translational hurdles, such as protein corona formation and in vivo stability, that limit clinical progression

It is a naturally occurring nonapeptide a chain of nine amino acids first identified in rabbit brain tissue in the 1970s

10.1016/j.bbrc.2022.03.026 266 ZhangJ.GaoR.-F.LiJ.YuK.-d.BiK.-X

NMDA receptors are associated with glutamate, an essential excitatory neurotransmitter in the brain, while GABA receptors are linked to inhibitory neurotransmission, which is considered crucial for reducing neural activity and inducing a relaxed state