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Reactive oxygen and nitrogen species (ROS/RNS) play a central role in this toxicity, supporting the development of antioxidant-based interventions to mitigate APAP-induced damage

An imbalance of T H 1/T H 2-cell responses is thought to contribute to the pathogenesis of various infections, allergic responses and autoimmune diseases

While this guideline addresses recombinant GH rather than secretagogues, it frames the clinical rationale for GH-axis optimization in symptomatic adults with documented deficiency