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These symptoms could suggest central nervous system involvement beyond peripheral sensitization
It is one of the most widely discussed incretin research areas
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Intestinal proglucagon cleaves (breaks up) into several different molecules: GLP-1 GLP-2 GRPP Oxyntomodulin The enzyme PCSK1 converts proglucagon to GLP-1 in the central nervous system
Appraisal results were summarized as low, moderate, or high risk of bias, and a global level of evidence was assigned using an adapted GRADE framework [12]
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