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Upon binding to biologically active HGF, c-Met undergoes dimerization and recruits downstream signaling effector molecules, including PI3K, PLC-?1, and STAT3
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The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose
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